Chang H T, Mok K T, Tzeng W S
Department of Surgery, Veterans General Hospital-Kaohsiung, School of Medicine, National Yang-Ming University, Taiwan, R.O.C.
Am J Clin Oncol. 1997 Oct;20(5):493-9. doi: 10.1097/00000421-199710000-00012.
Eleven patients with T4 breast cancer received induction intraarterial chemotherapy (IACT) as the first step in multidisciplinary therapy. The IACT agents (epirubicin and mitomycin C), were delivered weekly in the outpatient department by bolus injection through an implantable port-catheter system. A modified technique of port-catheter system implantation was used. The precise localization of the catheter was dually confirmed by angiography and dye test. The effectiveness of the treatment was evaluated by clinical appearance, image study, and microscopic examination. A 91% response rate was obtained, and the lesions were resectable in < or = 8 weeks. No obvious systemic toxicity resulted from the IACT. Our results show that weekly IACT by bolus injection through a port-catheter system for treating locally advanced T4 breast cancer is feasible and efficacious.
11例T4期乳腺癌患者接受了诱导性动脉内化疗（IACT），作为多学科治疗的第一步。IACT药物（表柔比星和丝裂霉素C）通过植入式端口导管系统每周在门诊进行推注给药。采用了一种改良的端口导管系统植入技术。通过血管造影和染料试验双重确认导管的精确定位。通过临床表现、影像学检查和显微镜检查评估治疗效果。有效率为91%，且病变在小于或等于8周内可切除。IACT未导致明显的全身毒性。我们的结果表明，通过端口导管系统每周推注IACT治疗局部晚期T4期乳腺癌是可行且有效的。
