Kaji M, Kusuhara T, Ayabe M, Hino H, Shoji H, Nagao T
First Department (Neurology) of Internal Medicine, Kurume University School of Medicine, Japan.
Mult Scler. 1996 Sep;2(2):83-7. doi: 10.1177/135245859600200204.
We analysed data from 27 patients with herpes simplex virus (HSV) infections of the central nervous system (CNS) found in a 1990-1992 survey in Kyushu and Okinawa, Japan. Patients ranged in age from one year to 70 years, with peaks seen in the 20s and 50s. Temporal lobe-limbic encephalitis was the most common HSV infection (13 patients), followed by meningitis (5), diffuse encephalitis (4), disseminated encephalomyelitis (ADEM) (3) and brain stem encephalitis (2). Another three patients with non-herpetic, non-paraneoplastic acute limbic encephalitis were presented. Our study indicates that HSV infection can course ADEM, although temporal lobe-limbic encephalitis or meningitis are more common. The early diagnosis of HSV-related ADEM is important because of the efficacy of the timely administration of corticosteroids.
我们分析了1990年至1992年在日本九州和冲绳进行的一项调查中发现的27例中枢神经系统（CNS）单纯疱疹病毒（HSV）感染患者的数据。患者年龄从1岁到70岁不等，20多岁和50多岁时出现两个高峰。颞叶-边缘性脑炎是最常见的HSV感染类型（13例患者），其次是脑膜炎（5例）、弥漫性脑炎（4例）、播散性脑脊髓炎（ADEM）（3例）和脑干脑炎（2例）。另外还报告了3例非疱疹性、非副肿瘤性急性边缘性脑炎患者。我们的研究表明，尽管颞叶-边缘性脑炎或脑膜炎更为常见，但HSV感染可引发ADEM。由于及时使用皮质类固醇激素具有疗效，因此HSV相关ADEM的早期诊断很重要。
