Bever C T, Grattan L, Panitch H S, Johnson K P
Department of Neurology, University of Maryland School of Medicine, Baltimore 21201, USA.
Mult Scler. 1995 Nov;1(3):165-9. doi: 10.1177/135245859500100306.
The Brief Repeatable Battery of Neuropsychological Tests (BRB-N) for MS consisting of the selective reminding, 10/36 spatial recall, symbol digit modalities, paced auditory serial addition (PASAT) and word list generation tests is a sensitive measure of early cognitive impairment in MS patients. We administered it to 19 chronic stable MS patients every 60 days for 120 days to examine variability. The mean coefficient of variation for the tests ranged from 18% to 22%. A significant practice effect was seen in the PASAT results (P < 0.05) using the Wilcoxon signed rank test. These results suggest that cognitive fluctuations analogous to motor fluctuations may occur in MS patients and that the BRB-N may be useful in clinical trials of agents expected to alter cognitive function in MS patients if test-retest variability and practice effects are taken into account. Further study is warranted.
用于多发性硬化症（MS）的简短可重复神经心理学测试组（BRB-N），包括选择性回忆、10/36空间回忆、符号数字模式、听觉节律性连续加法测试（PASAT）和单词列表生成测试，是MS患者早期认知障碍的敏感测量方法。我们每60天对19名慢性稳定MS患者进行一次BRB-N测试，共进行120天，以检查变异性。测试的平均变异系数在18%至22%之间。使用Wilcoxon符号秩检验，在PASAT结果中观察到显著的练习效应（P < 0.05）。这些结果表明，MS患者可能会出现类似于运动波动的认知波动，如果考虑到重测变异性和练习效应，BRB-N可能有助于预期改变MS患者认知功能的药物的临床试验。有必要进行进一步研究。
