Amunts K, Schlaug G, Schleicher A, Steinmetz H, Dabringhaus A, Roland P E, Zilles K
C.&O. Vogt Brain Research Institute, Heinrich Heine University, Düsseldorf, Germany.
Neuroimage. 1996 Dec;4(3 Pt 1):216-22. doi: 10.1006/nimg.1996.0073.
Handedness is one of the most obvious functional asymmetries, but its relation to an anatomical asymmetry of the hand representation area in the motor cortex has not been demonstrated. This would be a crucial test for the hypothesis of structure-function correlation in cortical motor organization. Using magnetic resonance morphometry, we show for the first time that the depth of the central sulcus is related to handedness. In right-handers, the left central sulcus is deeper than the right, and vice versa in left-handers. Macrostructural asymmetry is complemented by a microstructural left-larger-than-right asymmetry in neuropil volume (i.e., tissue compartment containing dendrites, axons, and synapses) in Brodmann's area 4. These asymmetries suggest that hand preference is associated with increased connectivity (demonstrated by an increased neuropil compartment in left area 4) and an increased intrasulcal surface of the precentral gyrus in the dominant hemisphere.
利手是最明显的功能不对称之一，但其与运动皮层中手部代表区解剖学不对称的关系尚未得到证实。这将是对皮质运动组织中结构-功能相关性假说的关键检验。使用磁共振形态测量法，我们首次表明中央沟的深度与利手有关。在右利手中，左侧中央沟比右侧深，而在左利手中则相反。宏观结构不对称由布罗德曼4区神经毡体积（即包含树突、轴突和突触的组织隔室）中左侧大于右侧的微观结构不对称所补充。这些不对称表明，手偏好与优势半球中连接性增加（通过左侧4区神经毡隔室增加来证明）和中央前回沟内表面增加有关。
