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酸中毒、局部麻醉药与新生儿

Acidosis, local anesthetics, and the newborn.

作者信息

Brown W U, Bell G C, Alper M H

出版信息

Obstet Gynecol. 1976 Jul;48(1):27-30.

PMID:934571
Abstract

Four newborn infants were studied following maternal epidural block with lidocaine or mepivacaine. Each of these neonates, born with a pH of 7.23 or below in the umbilical vein blood, showed an elevated fetal-to-maternal concentration ratio, a possible manifestation of ion trapping of a weak base.

摘要

对4例在母亲接受利多卡因或甲哌卡因硬膜外阻滞术后的新生儿进行了研究。这些新生儿脐静脉血pH值均在7.23及以下,每例新生儿的胎儿与母体浓度比均升高,这可能是弱碱离子捕获的一种表现。

相似文献

1
Acidosis, local anesthetics, and the newborn.酸中毒、局部麻醉药与新生儿
Obstet Gynecol. 1976 Jul;48(1):27-30.
2
Perinatal deaths associated with mepivacaine paracervical-block anesthesia in labor.
N Engl J Med. 1968 Mar 7;278(10):530-3. doi: 10.1056/NEJM196803072781003.
3
Epidural bupivacaine, chloroprocaine, or lidocaine for cesarean section--maternal and neonatal effects.剖宫产术中硬膜外使用布比卡因、氯普鲁卡因或利多卡因——对母体和新生儿的影响
Anesth Analg. 1983 Oct;62(10):914-9.
4
[The effect of paracervical block on the fetus].
Anaesthesist. 1972 Mar;21(3):91-4.
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Transient maternal hypotension following epidural anesthesia.
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6
[Hazards of paracervical block in obstetrics. A survey of 107 hospitals for women with a total of 32, 652 cases].
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Maternal, fetal, and neonatal effects of lidocaine with and without epinephrine for epidural anesthesia in obstetrics.
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Letter: Obstetric analgesia and the newborn baby.
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Bedside cesarean section due to total spinal block after epidural anesthesia for labor pain.
Int J Obstet Anesth. 2006 Jan;15(1):87-8. doi: 10.1016/j.ijoa.2005.09.002. Epub 2005 Dec 1.
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[Lidocaine intoxication in newborn following maternal pudendal anesthesia: report of three cases].[产妇阴部麻醉后新生儿利多卡因中毒:三例报告]
J Gynecol Obstet Biol Reprod (Paris). 2008 Jun;37(4):415-8. doi: 10.1016/j.jgyn.2008.01.010. Epub 2008 Apr 10.

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Drug Transporters Expressed in the Human Placenta and Models for Studying Maternal-Fetal Drug Transfer.人胎盘表达的药物转运体及其用于研究母胎药物转运的模型。
J Clin Pharmacol. 2019 Sep;59 Suppl 1(Suppl 1):S70-S81. doi: 10.1002/jcph.1491.
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Maternal cardiac arrhythmias during pregnancy and lactation.孕期和哺乳期的母体心律失常
Obstet Med. 2010 Mar;3(1):8-16. doi: 10.1258/om.2009.090021. Epub 2010 Mar 4.
3
[Anesthetic regimen for HIV positive parturients undergoing elective cesarean section].
Anaesthesist. 2003 Dec;52(12):1124-31. doi: 10.1007/s00101-003-0597-5.
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Treatment of cardiac arrhythmias during pregnancy: safety considerations.孕期心律失常的治疗:安全性考量
Drug Saf. 1999 Jan;20(1):85-94. doi: 10.2165/00002018-199920010-00008.
5
Adverse effects and drug interactions associated with local and regional anaesthesia.与局部和区域麻醉相关的不良反应及药物相互作用。
Drug Saf. 1998 Apr;18(4):221-50. doi: 10.2165/00002018-199818040-00001.
6
Drug kinetics in childbirth.分娩中的药物动力学。
Clin Pharmacokinet. 1980 Jul-Aug;5(4):340-64. doi: 10.2165/00003088-198005040-00003.
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The effect of lidocaine on regional blood flows and cardiac output in the non-stressed and the stressed foetal lamb.利多卡因对未受应激和受应激的胎羊局部血流及心输出量的影响。
Can Anaesth Soc J. 1986 Mar;33(2):130-7. doi: 10.1007/BF03010821.
8
Anaesthetic considerations in high-risk pregnancy.高危妊娠的麻醉注意事项
Can Anaesth Soc J. 1986 May;33(3 Pt 2):S16-27. doi: 10.1007/BF03019152.
9
Disposition of the adrenergic blocker metoprolol and its metabolite OH-metoprolol in maternal plasma, amniotic fluid and capillary blood of the neonate.肾上腺素能阻滞剂美托洛尔及其代谢产物OH-美托洛尔在母体血浆、羊水和新生儿毛细血管血中的分布情况。
Eur J Clin Pharmacol. 1987;33(4):363-8. doi: 10.1007/BF00637631.
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The pharmacokinetics of antiarrhythmic agents in pregnancy and lactation.抗心律失常药物在妊娠和哺乳期的药代动力学。
Clin Pharmacokinet. 1987 Apr;12(4):253-91. doi: 10.2165/00003088-198712040-00002.