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[产妇阴部麻醉后新生儿利多卡因中毒:三例报告]

[Lidocaine intoxication in newborn following maternal pudendal anesthesia: report of three cases].

作者信息

Pagès H, de la Gastine B, Quedru-Aboane J, Guillemin M-G, Lelong-Boulouard V, Guillois B

机构信息

Service de néonatalogie, CHRU, avenue Georges-Clémenceau, 14033 Caen cedex, France.

出版信息

J Gynecol Obstet Biol Reprod (Paris). 2008 Jun;37(4):415-8. doi: 10.1016/j.jgyn.2008.01.010. Epub 2008 Apr 10.

Abstract

Pudendal nerve block may be indicated during instrumental delivery in situations where peridural anesthesia is unavailable. We report three cases of neonatal lidocaine intoxication following maternal pudendal block during delivery. Clinical features were hypotonia, pupillary mydriasis fixed to light, apnea, cyanosis and seizures. Two neonates required mechanical ventilation. Lidocaine was found in the serum of two babies. In all three cases, recovery was complete. The pharmacokinetics of lidocaine in a highly vascularized perineum during labor increase the risk of neonatal intoxication. A possible intoxication by local anesthetics should be considered in neonates presenting an acute distress in the delivery room.

摘要

在无法进行硬膜外麻醉的情况下,器械助产时可能需要阴部神经阻滞。我们报告了3例分娩期间产妇阴部阻滞导致新生儿利多卡因中毒的病例。临床特征为肌张力减退、对光固定性瞳孔散大、呼吸暂停、发绀和惊厥。2例新生儿需要机械通气。在2例婴儿的血清中发现了利多卡因。所有3例均完全康复。分娩时高度血管化的会阴部位利多卡因的药代动力学增加了新生儿中毒的风险。对于在产房出现急性窘迫的新生儿,应考虑局麻药中毒的可能性。

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