Phoenix D A, Korotkov E
Department of Applied Biology, University of Central Lancashire, Preston, UK.
FEMS Microbiol Lett. 1997 Oct 1;155(1):63-6. doi: 10.1111/j.1574-6968.1997.tb12686.x.
It is known that there is a high occurrence of rare codons at the start of coding region. Here it is shown that although the remainder of the gene is likely to contain a relatively low number of rare codons, rare and non-rare codons do not form a random sequence. It is apparent that throughout the coding region there is a higher than expected number of rare codon clusters. For example once a rare codon has occurred there is a greater chance than expected of the next six codons containing another rare codon. This non-random distribution implies that rare codons may have an as yet unidentified biological role.
众所周知，在编码区域起始处稀有密码子的出现频率很高。此处表明，尽管基因的其余部分可能含有相对较少数量的稀有密码子，但稀有密码子和非稀有密码子并非形成随机序列。很明显，在整个编码区域中，稀有密码子簇的数量高于预期。例如，一旦出现一个稀有密码子，接下来的六个密码子中包含另一个稀有密码子的可能性就比预期的要大。这种非随机分布意味着稀有密码子可能具有尚未确定的生物学作用。
