Gerhardt C C, van Heerikhuizen H
Department of Biochemistry and Molecular Biology, Research Institute Neurosciences, Vrije Universteit, Amsterdam, The Netherlands.
Eur J Pharmacol. 1997 Sep 3;334(1):1-23. doi: 10.1016/s0014-2999(97)01115-1.
Over the past 10 years, molecular cloning has revealed the presence of 15 serotonin (5-hydroxytryptamine; 5-HT) receptor subtypes, which can be subdivided in seven subfamilies. Except for the 5-HT3 receptors, which are ligand-gated ion channels, all 5-HT receptors belong to the superfamily of G-protein-coupled receptors. The large multiplicity of 5-HT receptor subtypes has been suggested to be a direct result of the evolutionary age of the 5-HT system. Molecular information on G-protein-coupled 5-HT receptors is currently available for several mammalian species as well as for a limited number of invertebrate species (insects, molluscs). The aim of this review is to give an overview of all cloned 5-HT receptor subtypes belonging to the superfamily of G-protein-coupled receptors with specific emphasis on the pharmacological and signaling properties of the receptors upon expression in several heterologous expression systems.
在过去10年里，分子克隆技术已揭示出15种血清素（5-羟色胺；5-HT）受体亚型，这些亚型可进一步细分为7个亚家族。除了作为配体门控离子通道的5-HT3受体外，所有5-HT受体均属于G蛋白偶联受体超家族。5-HT受体亚型的多样性被认为是5-HT系统进化年代久远的直接结果。目前，关于G蛋白偶联5-HT受体的分子信息在几种哺乳动物以及数量有限的无脊椎动物物种（昆虫、软体动物）中均有报道。本综述的目的是概述属于G蛋白偶联受体超家族的所有克隆5-HT受体亚型，特别强调这些受体在几种异源表达系统中表达时的药理学和信号特性。
