HLA in southern Thai-Muslims.

UNLABELLED

One hundred and two Southern Thai-Muslims (STM) from Nakhon Si Thammarat province were studied for HLA class I and II by SSP ARMS-PCR and PCR-SSO, respectively. The allele frequencies, haplotype frequencies, delta value and linkage disequilibrium between alleles were expressed. The most frequent alleles for HLA-A, HLA-B and HLA-C were A24(02,03), A11 (01,02), A02(01,03,05-07,11): B15(01,04-07,12,19,20), B07(02-05), B51(01-05)/B52 (011,012); and Cw07(01-03), Cw04(01,02), Cw08(01-03), respectively. The HLA class II alleles frequently found were DRB11202, DRB115021, DRB10701; DRB30301; DRB5* 0101; DQA10101, DQA10103, DQA10601; DQB10301, DQB10501, DQB10201; and DPB11301, DPB12301 and DPB10501. Two common HLA class I and II haplotypes with significant linkage disequilibrium were A24 (02,03)-Cw08 (01-03)-B15 (01,04-07,12,19,20) -DRB11202 and A33 (01,02)-Cw0302-B5801-DQB10201. The absence of B27 and DRB1 1401, the presence of A2301 and high frequency of A*68 were observed in STM.

CONCLUSION

Certain level of genetically distinction among STM, CT and NET existed. However, the genetic diversity of STM was relatively closer to CT than NET.