Maneemaroj R, Stephens H A, Chandanayingyong D, Longta K, Bejrachandra S
Department of Pathology, Pramongkutklao College of Medicine, Bangkok, Thailand.
J Med Assoc Thai. 1997 Sep;80 Suppl 1:S20-4.
The polymorphism of HLA class II genes (HLA-DRB1, -DQA1, -DQB1 and -DPB1) was investigated in 97 normal Northern Thais (NT) from Kamphaeng Phet province using PCR-SSO typing. Allele frequencies (AF) have been determined. DRB11202 (17.5%), DRB11502 (16.5%), DQA10101 (25.8%), DQA10102 (21.7%), DQB10502 (22.7%), DPB10501 (23.2%) and DPB1*1301 (22.7%) showed the highest frequencies in each locus. These results were more similar to those observed in Present-day Thais (PDT) and Central Thais (CT) than Northern Thais from Chiang Mai (CM) and Dai Lue (DL). However, the data presented in this population study should be useful in many fields, such as anthropology, organ transplantation, disease susceptibility and evolutionary genetics.
采用聚合酶链反应-序列特异性寡核苷酸分型法（PCR-SSO），对来自彭世洛府的97名正常泰国北部人（NT）的人类白细胞抗原II类基因（HLA-DRB1、-DQA1、-DQB1和-DPB1）多态性进行了研究。已确定等位基因频率（AF）。DRB11202（17.5%）、DRB11502（16.5%）、DQA10101（25.8%）、DQA10102（21.7%）、DQB10502（22.7%）、DPB10501（23.2%）和DPB1*1301（22.7%）在每个基因座中显示出最高频率。这些结果与现今泰国人（PDT）和泰国中部人（CT）中观察到的结果比与清迈的泰国北部人（CM）和傣泐人（DL）中观察到的结果更相似。然而，该群体研究中呈现的数据在许多领域应会有用，如人类学、器官移植、疾病易感性和进化遗传学。
