Brevik E M
Nord Vet Med. 1976 Apr-May;28(4-5):226-32.
The plastizicer di(2-ethylhexyl)phthalate (DEHP) is produced in hundreds of thousands tons and has got a widespread use in a multitude of PVC-plast products. In the present review the toxicology and possible harmful environmental effects of DEHP is discussed. The four following topics have also been considered: 1. The solubility of DEHP in water and the complex between DEHP and fulvic acid. 2. Residues and metabolites of DEHP in fish and invertebrates. 3. The metabolites of DEHP in rat, where four major metabolites have been found (fig. 1). 4. The problem concerning residues of DEHP in blood stored in PVC plastic bags for transfusion and the relationship of DEHP to microaggregation of platelets in stored blood. Although the oral LD50 in the rat, mouse and rabbit is about 30 g/kg, its toxicology reveals problematic features such as high toxicity to some invertebrates, specific effects on the nervous system of fish and teratogenic effects in rats.
增塑剂邻苯二甲酸二（2-乙基己基）酯（DEHP）的年产量达数十万吨，在众多聚氯乙烯塑料制品中广泛使用。在本综述中，讨论了DEHP的毒理学及其可能对环境产生的有害影响。还考虑了以下四个主题：1. DEHP在水中的溶解度以及DEHP与富里酸之间的络合物。2. DEHP在鱼类和无脊椎动物中的残留及代谢产物。3. DEHP在大鼠体内的代谢产物，已发现四种主要代谢产物（图1）。4. 储存在聚氯乙烯输血塑料袋中的血液中DEHP残留问题以及DEHP与储存血液中血小板微聚集的关系。尽管大鼠、小鼠和兔子的经口半数致死量约为30 g/kg，但其毒理学显示出一些问题特征，如对某些无脊椎动物毒性高、对鱼类神经系统有特定影响以及对大鼠有致畸作用。
