Peck C C, Albro P W
Environ Health Perspect. 1982 Nov;45:11-7. doi: 10.1289/ehp.824511.
Although human toxicity from exposure to the plasticizer di(2-ethylhexyl) phthalate (DEHP) is unknown, reports of animal toxicity from DEHP have stimulated extensive toxicological studies. In the absence of direct toxicity data, information on the disposition and metabolism of DEHP in primates and man may enhance our assessment of the toxic potential of DEHP in man. Studies of DEHP disposition and metabolism in the African Green monkey and man show that the compound is rapidly and extensively metabolized. It is excreted largely in the urine (greater than 90%) as conjugated (glucuronide) oxidation products of mono(2-ethylhexyl) phthalate; excretion in feces accounts for the other 10% of the administered DEHP. Plasma disappearance of parenterally administered DEHP is equally rapid so that by 24 hr following DEHP administration, plasma DEHP concentrations are virtually undetectable, while greater than 70% of the dose has been excreted in urine and stool. The transience of DEHP in primates and the extent to which it is metabolized and conjugated may play a role in the observed lack of toxicity.
虽然接触增塑剂邻苯二甲酸二（2-乙基己基）酯（DEHP）对人类的毒性尚不清楚，但有关DEHP对动物毒性的报道激发了广泛的毒理学研究。在缺乏直接毒性数据的情况下，关于DEHP在灵长类动物和人类体内的处置和代谢信息，可能会增强我们对DEHP对人类潜在毒性的评估。对非洲绿猴和人类体内DEHP处置和代谢的研究表明，该化合物能迅速且广泛地被代谢。它主要以单（2-乙基己基）邻苯二甲酸酯的共轭（葡萄糖醛酸）氧化产物形式经尿液排出（超过90%）；经粪便排出的量占所给予DEHP的另外10%。经肠胃外给予的DEHP在血浆中的消失同样迅速，以至于在给予DEHP后24小时，血浆中DEHP浓度几乎检测不到，而超过70%的剂量已通过尿液和粪便排出。DEHP在灵长类动物体内的短暂性以及其被代谢和共轭的程度，可能在观察到的无毒性现象中起作用。
