Varela F, Font X, Valladares J E, Alberola J
Centre Mèdic Veterinari de Barcelona, Spain.
J Vet Intern Med. 1997 Sep-Oct;11(5):309-11. doi: 10.1111/j.1939-1676.1997.tb00471.x.
A 6-year-old dog was presented for evaluation of recurrent epistaxis. Platelet counts, biochemical tests, and coagulation tests were within the normal range, but a mucosal bleeding time was prolonged; there was hyperproteinemia and a monoclonal gammopathy. Heterogeneity of light chains appeared in urine, however, thus suggesting that the gammopathy was polyclonal. Platelet aggregation tests showed decreased responsiveness to collagen. An Ehrlichia canis indirect fluorescent-antibody titer was positive (1:40). Treatment with tetracycline, melphalan, and prednisone resulted in a rapid clinical improvement that persisted for at least 3 years.
一只6岁的犬只因反复鼻出血前来评估。血小板计数、生化检查和凝血检查均在正常范围内，但黏膜出血时间延长；存在高蛋白血症和单克隆丙种球蛋白病。然而，尿液中出现轻链异质性，因此提示丙种球蛋白病为多克隆性。血小板聚集试验显示对胶原的反应性降低。犬埃立克体间接荧光抗体效价为阳性（1:40）。用四环素、美法仑和泼尼松治疗后临床迅速改善，并持续了至少3年。
