Aoki N, Soma K, Katagiri H, Aizawa Y, Kadowaki T, Ohwada T
Department of Emergency and Critical Care Medicine, Kitasato University School of Medicine, Sagamihara, Japan.
Ind Health. 1997 Oct;35(4):451-5. doi: 10.2486/indhealth.35.451.
We examined the hemodynamic effects of 1,1,1-trichloroethane (TCE) inhalation in anesthetized dogs in acute inhalation experiments. Six adult mongrel dogs with spontaneous respiration were intubated, connected to a one-way valve. TCE was delivered by the tubular system connected to a 30-liter tedlar bag reservoir filled with 1 v/v% of TCE. After TCE inhalation, the animals revealed a significant decrease in systemic arterial pressure following a decrease in systemic vascular resistance. Pulmonary arterial pressure, pulmonary vascular resistance and right cardiac work increased significantly. These changes were compatible with clinical manifestations of TCE intoxication in human beings. In conclusion, inhalation of TCE may not only decrease peripheral vascular resistance, but also induce transient disturbance of pulmonary blood flow with subsequent pressure overloading in the right ventricle.
在急性吸入实验中，我们研究了麻醉犬吸入1,1,1-三氯乙烷（TCE）后的血流动力学效应。六只具有自主呼吸的成年杂种犬经气管插管，连接至单向阀。TCE通过连接到装有1 v/v% TCE的30升泰德拉袋储存器的管道系统输送。吸入TCE后，动物的体循环血管阻力降低，随后体循环动脉压显著下降。肺动脉压、肺血管阻力和右心功显著增加。这些变化与人类TCE中毒的临床表现相符。总之，吸入TCE不仅可能降低外周血管阻力，还可能导致肺血流的短暂紊乱，随后右心室压力过载。
