Kobayashi H, Hobara T, Satoh T, Sakai T
Arch Environ Health. 1986 May-Jun;41(3):149-54. doi: 10.1080/00039896.1986.9935769.
The effects of 1,1,1-trichloroethane (1,1,1-TCE) inhalation on respiration and afferent activity of the lung stretch receptor were investigated in anesthetized dogs. In acute inhalation experiments, rapid and shallow breathing was observed following inhalation of high 1,1,1-TCE concentrations. The threshold concentration of 1,1,1-TCE to produce an increase in respiratory rate was approximately 0.9% in inspired air. Moreover, a dose-response relationship was observed between the increase in respiratory rate and concentrations which exceeded the threshold level. An inspiratory action of respiration markedly decreased for high 1,1,1-TCE concentrations. Both the increase in respiratory rate and the decrease in the inspiratory action for high 1,1,1-TCE concentrations were significantly inhibited, however, these reactions were not completely blocked by bilateral vagotomy. Afferent impulses of the lung stretch receptor in the vagus nerve obviously increased following 1,1,1-TCE whose concentrations were more than 0.9% in inspired air. It is suggested that rapid and shallow breathing following higher 1,1,1-TCE concentrations may be related to the increase in the activity of the lung stretch receptor. It is further suggested that a part of rapid and shallow breathing is not based on anesthetic effects but enhancement of Hering Breuer reflex following 1,1,1-TCE inhalation.
在麻醉犬中研究了吸入1,1,1-三氯乙烷（1,1,1-TCE）对呼吸及肺牵张感受器传入活动的影响。在急性吸入实验中，吸入高浓度1,1,1-TCE后观察到呼吸急促且浅。吸入空气中1,1,1-TCE引起呼吸频率增加的阈浓度约为0.9%。此外，在超过阈浓度的情况下，观察到呼吸频率增加与浓度之间存在剂量反应关系。高浓度1,1,1-TCE时呼吸的吸气动作明显减弱。高浓度1,1,1-TCE时呼吸频率增加和吸气动作减弱均受到显著抑制，然而，双侧迷走神经切断术并未完全阻断这些反应。吸入空气中1,1,1-TCE浓度超过0.9%后，迷走神经中肺牵张感受器的传入冲动明显增加。提示较高浓度1,1,1-TCE后出现的呼吸急促且浅可能与肺牵张感受器活动增加有关。进一步提示，部分呼吸急促且浅并非基于麻醉作用，而是吸入1,1,1-TCE后黑林-布雷尔反射增强所致。
