Wen M C, Chen J T, Ho W L
Department of Pathology, Taichung Veterans General Hospital, Taiwan, Republic of China.
Kaohsiung J Med Sci. 1997 Sep;13(9):534-9.
In a quality assurance study we reviewed one thousand four hundred and forty-three consecutive frozen sections performed at department of pathology, VGH-TC from June 1995 to July 1996. The diagnostic accuracy was 92.6%. The diagnosis was deferred in sixty-eight cases (4.7%). False positive for malignant tumor was made in two cases (0.14%) and false negative diagnosis for malignancy in thirty-seven (2.56%). The inaccurate diagnosis was mainly in samples taken from the brain, female breast, and thyroid. Incorrect diagnoses were mainly due to interpretation of the pathologic findings (71.8%), followed by gross sampling (15.4%) and microscopic sampling (12.8 %). Some of the lesions were difficult to diagnose even in permanent sections. Technical skill and diagnostic expertise are essential for frozen diagnosis. We suggest that an accuracy survey of frozen section be periodically performed in every pathology department as part of its quality assurance program.
在一项质量保证研究中，我们回顾了1995年6月至1996年7月在台北荣民总医院病理科连续进行的1443例冰冻切片。诊断准确率为92.6%。68例（4.7%）诊断被延迟。恶性肿瘤假阳性2例（0.14%），恶性肿瘤假阴性诊断37例（2.56%）。诊断不准确主要发生在取自脑、女性乳腺和甲状腺的样本中。诊断错误主要是由于对病理结果的解读（71.8%），其次是大体取材（15.4%）和显微镜取材（12.8%）。即使在永久切片中，一些病变也难以诊断。技术技能和诊断专业知识对于冰冻诊断至关重要。我们建议每个病理科定期进行冰冻切片准确性调查，作为其质量保证计划的一部分。
