Rakha E, Ramaiah S, McGregor A
Department of Histopathology, Leicester Royal Infirmary, University Hospitals of Leicester NHS Trust, Leicester, UK.
J Clin Pathol. 2006 Apr;59(4):352-4. doi: 10.1136/jcp.2005.029538. Epub 2006 Feb 17.
To evaluate the diagnostic accuracy of intraoperative frozen sections diagnosis of liver lesions thought to be malignant tumours.
285 frozen sections of liver from 173 patients were reviewed. The examinations were done between 1998 and 2004.
Final histological diagnosis was divided into positive (32%) and negative (68%) for malignancy. In four cases (2%), diagnosis was deferred to paraffin section. There was one false positive and two false negative diagnoses. Sensitivity was 96.9% and specificity was 99.1%, and the overall accuracy to determine the lesions was 95%. The cases were further analysed to ascertain the nature of diagnostic difficulties, which comprised pathological misinterpretation, sampling error, and technical imperfections. Biliary hamartoma was the most common entity that was confused with malignant tumours in frozen sections.
The data are in accordance with those of similar studies in other sites, and confirm that the frozen section is an accurate and reliable method for intraoperative diagnosis of suspected liver lesions.
评估术中冰冻切片诊断疑似肝脏恶性肿瘤病变的诊断准确性。
回顾了173例患者的285份肝脏冰冻切片。检查于1998年至2004年期间进行。
最终组织学诊断分为恶性阳性（32%）和阴性（68%）。4例（2%）诊断推迟至石蜡切片。有1例假阳性和2例假阴性诊断。敏感性为96.9%，特异性为99.1%，确定病变的总体准确率为95%。对病例进行进一步分析以确定诊断困难的性质，包括病理误判、采样误差和技术缺陷。胆管错构瘤是冰冻切片中最常与恶性肿瘤混淆的实体。
这些数据与其他部位类似研究的数据一致，并证实冰冻切片是术中诊断疑似肝脏病变的准确可靠方法。
