慢性粒细胞白血病中的粒细胞特异性同种抗原缺失

Granulocyte-specific alloantigen loss in chronic granulocytic leukaemia.

作者信息

Reijden J H, von dem Borne A E, Verheugt F W, Floor-van Gent A B, Melief C J, Engelfriet C P

出版信息

Br J Haematol. 1979 Dec;43(4):589-94. doi: 10.1111/j.1365-2141.1979.tb03791.x.

DOI:10.1111/j.1365-2141.1979.tb03791.x

Abstract

The granulocytes of 23 patients with chronic granulocytic leukaemia were examined in the indirect immunofluorescence test and some also in the microleucoagglutination test, with specific alloantisera against the NA1, NA2, NB1 and ND1 antigens and a specific granulocyte xenoantiserum. In 10 cases a complete loss of alloantigens was detected. In one patient a partial loss was found. A significant correlation was established between this loss and an accelerated activity (impending blast crisis) of the disease.

摘要

对23例慢性粒细胞白血病患者的粒细胞进行了间接免疫荧光试验检测，部分患者还进行了微白细胞凝集试验，使用针对NA1、NA2、NB1和ND1抗原的特异性同种抗血清以及一种特异性粒细胞异种抗血清。在10例患者中检测到同种抗原完全缺失。在1例患者中发现部分缺失。这种缺失与疾病的加速活动（即将发生原始细胞危象）之间建立了显著相关性。