Tang W Y, Lo J Y, Yuen M K, Lam W Y
Social Hygiene Clinic, Lek Yuen Health Centre, Shatin, NT, Hong Kong.
Br J Dermatol. 1997 Sep;137(3):440-4.
A 5-year-old hyperkinetic but otherwise healthy child presented with recurrent irritable vesicles and erosions of the anterior chest wall; they have been apparent since the age of 15 months. Wound swab cultures yielded herpes simplex virus type-2 (HSV-2) and Western blot serology showed past exposure to both HSV-1 and HSV-2. Skin biopsy results further supported a herpes virus infection. Magnetic resonance imaging of the brain showed right temporal lobe atrophy. An evaluation showed no evidence of sexual abuse in the patient but a Western blot assay of the mother's serum for HSV-2 was positive, while the father's was negative. In view of the diagnosis of HSV-2 infection in such a young patient, the possible routes of transmission and the time of acquisition of infection were explored. We believe the most likely route of infection in this child was postnatal, through intimate contact with the mother.
一名5岁的儿童，除了患有多动症外身体健康，前胸壁反复出现刺激性水疱和糜烂；自15个月大以来就很明显。伤口拭子培养出2型单纯疱疹病毒（HSV-2），免疫印迹血清学显示既往曾接触过HSV-1和HSV-2。皮肤活检结果进一步支持疱疹病毒感染。脑部磁共振成像显示右侧颞叶萎缩。一项评估显示该患者没有性虐待的迹象，但对母亲血清进行的HSV-2免疫印迹检测呈阳性，而父亲的检测结果为阴性。鉴于如此年幼的患者被诊断为HSV-2感染，探讨了可能的传播途径和感染时间。我们认为这个孩子最可能的感染途径是出生后通过与母亲的密切接触。
