不同基质制备的栓剂中氨基比林和苯巴比妥释放情况的研究。
Studies on aminophenazone and phenobarbital release from suppositories prepared on different bases.
作者信息
Piasecka H, Zakrzewski Z
出版信息
Pol J Pharmacol Pharm. 1976;28(2):199-203.
Employing in the studies in vitro the dynamic system, we investigated aminophenazone (APH) and phenobarbital (PHB) release through semipermeable membrane from suppositories prepared on different bases, namely. Massupol, Oleum Cacao, H-15 Witepsol, Imhausen Suppositorien Masse SB, 1500 polioxyethylene glycol. The rate of APH liberation was highest from Imhausen and lowest from H-15 Witepsol; PHB was released most rapidly from Oleum Cacao, the poorest results being observed in the case of polioxyethylene glycol.
我们采用体外动态系统研究了氨基比林（APH）和苯巴比妥（PHB）从不同基质制备的栓剂中通过半透膜的释放情况，这些基质分别为：聚乙二醇基质、可可油、H-15型半合成脂肪酸甘油酯、Imhausen栓剂基质SB、1500聚氧乙烯二醇。APH从Imhausen基质的栓剂中释放速率最高，从H-15型半合成脂肪酸甘油酯基质的栓剂中释放速率最低；PHB从可可油基质的栓剂中释放最快，在聚氧乙烯二醇基质的栓剂中释放效果最差。
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