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寻找HLA匹配供者:HLA-A*、-B*、-DRB1/3/4/5*等位基因及其与血清学定义的HLA-A、-B、-DR抗原相关性概述

The search for HLA-matched donors: a summary of HLA-A*, -B*, -DRB1/3/4/5* alleles and their association with serologically defined HLA-A, -B, -DR antigens.

作者信息

Hurley C K, Schreuder G M, Marsh S G, Lau M, Middleton D, Noreen H

机构信息

Subcommittee of the Quality Assurance Working Group of the World Marrow Donor Association, Leiden, The Netherlands.

出版信息

Tissue Antigens. 1997 Oct;50(4):401-18. doi: 10.1111/j.1399-0039.1997.tb02894.x.

Abstract

This report summarizes data obtained from several large studies including the WHO HLA Nomenclature Committee, the International Cell Exchange, UCLA, the British Society for Histocompatibility and Immunogenetics Rare Cell Exchange and the National Marrow Donor Program and individual laboratories aimed at identifying a serologic type for specific HLA-A,-B,-DRB allelic products. Alleles that are poorly characterized at the serologic level are indicated and an approach is suggested for obtaining the information needed to clarify their serologic typing. The tables provided will be useful in guiding searches for an unrelated donor in which patient and/or potential donors are typed either by serology or by DNA-based methods and will provide a "dictionary" of potential equivalents between HLA "types" obtained by the two methods.

摘要

本报告总结了从多项大型研究中获取的数据,这些研究包括世界卫生组织HLA命名委员会、国际细胞交换中心、加州大学洛杉矶分校、英国组织相容性与免疫遗传学稀有细胞交换中心、国家骨髓捐献计划以及各个旨在确定特定HLA-A、-B、-DRB等位基因产物血清学类型的实验室。文中指出了在血清学水平上特征描述不充分的等位基因,并提出了一种获取所需信息以阐明其血清学分型的方法。所提供的表格将有助于指导寻找无关供体,其中患者和/或潜在供体通过血清学或基于DNA的方法进行分型,并将提供两种方法所获得的HLA“类型”之间潜在等效物的“词典”。

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