大鼠肾小管中的一种激肽释放酶特异性抑制剂。

A kallikrein-specific inhibitor in rat kidney tubules.

作者信息

Geiger R, Mann K

出版信息

Hoppe Seylers Z Physiol Chem. 1976 Apr;357(4):553-8. doi: 10.1515/bchm2.1976.357.1.553.

DOI:10.1515/bchm2.1976.357.1.553

Abstract

A kallikrein inhibitor was found in tubules of the rat kidney and purified by chromatography on Sephadex G-100. The molecular weight of the inhibitor, estimated by gel filtration and dodecylsulfate electrophoresis, is about 4700. It inhibits the following kallikreins: porcine submanidbular and pancreatic kallikrein, rat kidney and urine kallikrein, and human urine and plasma kallikrein. An inhibition of bovine trypsin was not observed.

摘要

在大鼠肾脏的肾小管中发现了一种激肽释放酶抑制剂，并通过Sephadex G - 100柱色谱法进行了纯化。通过凝胶过滤和十二烷基硫酸盐电泳估计，该抑制剂的分子量约为4700。它能抑制以下激肽释放酶：猪颌下腺和胰腺激肽释放酶、大鼠肾脏和尿液激肽释放酶以及人尿液和血浆激肽释放酶。未观察到对牛胰蛋白酶的抑制作用。