Yokouchi J, Hirabayashi S, Kanesaka N, Baba S, Amino M, Abe K
Dept. of Radiology, Tokyo Medical College.
Gan To Kagaku Ryoho. 1997 Oct;24(13):1967-73.
The most appropriate time for administration was studied based on examination of the total number of leukocytes, differential white blood count, and the number of platelets in 30 cases in which 200 micrograms Romurtide (Nopia) was injected subcutaneously on the day of radiotherapy, 5 times a week, for 2 weeks, totally 10 times because leukopenia was caused during treatment with radiotherapy. It was recognized that the number of leukocytes, mainly neutrophils, increased from 1 week after starting administration of Romurtide to after the completion of administration (2 weeks after administration), except 1 week after completion of administration. The increasing effect in the number of platelets was not recognized, and it had decreased from at the completion of administration to 1 week after the completion of administration of Romurtide. The rate of completion of radiotherapy was 100% without any serious adverse events, but there were 4 cases in which fever was observed. Therefore, it is not very favorable to administer Romurtide immediately after radiation, taking account of the treatment period of radiotherapy. It is also considered that it would be necessary to start radiation after sufficient recovery of the number of leukocytes or increase in their number by using G-CSF preparation in cases in which the leukocyte count has fallen since starting radiation due to the influence of the preceding chemotherapy.
在30例患者中，于放疗当日皮下注射200微克罗穆替德（诺匹亚），每周5次，共2周，总计10次，因为放疗期间出现了白细胞减少，基于对这些患者白细胞总数、白细胞分类计数及血小板数量的检查，研究了最适宜的给药时间。结果发现，从开始使用罗穆替德给药1周后至给药结束（给药后2周），白细胞数量（主要是中性粒细胞）增加，但给药结束后1周除外。未观察到血小板数量有增加作用，且从罗穆替德给药结束至给药结束后1周血小板数量有所下降。放疗完成率为100%，未出现任何严重不良事件，但有4例观察到发热。因此，考虑到放疗的治疗周期，放疗后立即给予罗穆替德不是很适宜。还认为，在因先前化疗影响自开始放疗后白细胞计数下降的情况下，有必要在白细胞数量充分恢复或使用粒细胞集落刺激因子制剂使其数量增加后再开始放疗。
