Bourne L C, Rice-Evans C A
International Antioxidant Research Centre, UMDS-Guy's Hospital, London.
Free Radic Res. 1997 Sep;27(3):337-44. doi: 10.3109/10715769709065771.
The action of ferulic acid during the oxidation of LDL has been investigated using both copper ions and the haem protein metmyoglobin as pro-oxidants. The results demonstrate the ability of ferulic acid to act as a pro-oxidant when LDL oxidation is induced by copper at concentrations of the phenolic acid which are protective when the LDL oxidation is mediated by metmyoglobin. The suggested mechanism involves the reduction of Cu2+ to Cu+ by ferulic acid resulting in the production of the ferulic phenoxyl radical.
利用铜离子和血红素蛋白高铁肌红蛋白作为促氧化剂，研究了阿魏酸在低密度脂蛋白（LDL）氧化过程中的作用。结果表明，当LDL氧化由铜诱导时，阿魏酸在酚酸浓度下具有促氧化剂的作用，而当LDL氧化由高铁肌红蛋白介导时，这些酚酸浓度具有保护作用。推测的机制包括阿魏酸将Cu2+还原为Cu+，从而产生阿魏酚氧基自由基。
