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促甲状腺激素对介导抗甲状腺抗体细胞毒性过程的影响

[The effect of thyrotropic hormone on processes mediating the cytotoxicity of antithyroid antibodies].

作者信息

Faĭzullaeva Sh F, Artemova E P

出版信息

Probl Endokrinol (Mosk). 1976 May-Jun;22(3):56-7.

PMID:935090
Abstract

Administration of 3 units of thyrotropic hormone to rabbits with autoimmune thyroiditis and hypothyroidism led to reduction of the I131 absorption by the thyroid gland and to increase in the activity of proteolytic enzymes of the gland. Apparently, in autoimmune thyroiditis disturbances at the stages of the iodide incorporation into the gland were irreversible; proteolysis depression was apparently secondary. Possibly the mentioned disturbances were associated with the circulating antithyroid antibodies.

摘要

给患有自身免疫性甲状腺炎和甲状腺功能减退的兔子注射3单位促甲状腺激素,导致甲状腺对I131的摄取减少,且甲状腺蛋白水解酶的活性增加。显然,在自身免疫性甲状腺炎中,碘化物进入甲状腺阶段的紊乱是不可逆的;蛋白水解抑制显然是继发性的。上述紊乱可能与循环中的抗甲状腺抗体有关。

相似文献

1
[The effect of thyrotropic hormone on processes mediating the cytotoxicity of antithyroid antibodies].促甲状腺激素对介导抗甲状腺抗体细胞毒性过程的影响
Probl Endokrinol (Mosk). 1976 May-Jun;22(3):56-7.
2
[Effect of anti-thyroid antibodies on thyroid hormone secretion].[抗甲状腺抗体对甲状腺激素分泌的影响]
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J Clin Endocrinol Metab. 1981 Sep;53(3):476-9. doi: 10.1210/jcem-53-3-476.
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Thyroid function in experimental isoimmune thyroiditis.实验性自身免疫性甲状腺炎中的甲状腺功能
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Probl Endokrinol (Mosk). 1976;22(2):66-70.
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