Davies J, Trask C, Souhami R L
Cancer Treat Rep. 1979 Nov-Dec;63(11-12):1835-8.
Fifteen patients with widespread painful osseous metastases from breast cancer unresponsive to other systemic therapy were treated with mithramycin at dose levels usually used for treating Paget's disease. Ten patients had relief of pain, which was marked and rapid in onset in seven. Mobility was greatly improved in four patients. Healing of bone lesions did not occur and new lesions developed while treatment was being given. Clinical response was associated with a decrease in plasma alkaline phosphatase. Toxicity was mild and consisted of nausea in most patients and a slight decrease in platelet count in one patient. Mithramycin is a useful agent for palliation of painful bone metastases and should be considered for further trials of combination chemotherapy for advanced breast cancer with bone metastases.
15例患有广泛疼痛性骨转移的乳腺癌患者，对其他全身治疗无反应，接受了通常用于治疗佩吉特病的剂量水平的光辉霉素治疗。10例患者疼痛缓解，其中7例起效显著且迅速。4例患者的活动能力得到极大改善。在治疗期间，骨病变未愈合且出现了新的病变。临床反应与血浆碱性磷酸酶降低有关。毒性轻微，大多数患者出现恶心，1例患者血小板计数略有下降。光辉霉素是缓解疼痛性骨转移的有效药物，应考虑用于晚期伴有骨转移的乳腺癌联合化疗的进一步试验。
