Watson C P, Evans R J
Can Med Assoc J. 1982 Feb 1;126(3):263-6.
This study examines retrospectively the cause, clinical features, natural history and results of treatment of intractable pain associated with breast cancer in 210 patients. The three chief types of pain were that due to skeletal metastases or brachial plexus neuropathy and pain of psychogenic origin. Onset at the time of cancer diagnosis characterized the psychogenic pain, whereas pain from metastases first occurred after a median latency of 3.7 years. Treatment was custom-tailored to the specific patient and pain problem, with several factors taken into account. The onset of intractable pain due to metastatic disease indicated a short survival (median, 9 months).
本研究回顾性分析了210例乳腺癌相关顽固性疼痛患者的病因、临床特征、自然病程及治疗结果。疼痛的三种主要类型为骨转移或臂丛神经病变所致疼痛以及心因性疼痛。心因性疼痛在癌症诊断时发作，而转移所致疼痛首次出现的中位潜伏期为3.7年。治疗是根据特定患者和疼痛问题量身定制的，同时考虑了几个因素。转移性疾病所致顽固性疼痛的发作表明生存期较短（中位生存期为9个月）。
