Mignon F, Galmiche J P, Accary J P, Mignon M F
Proc Eur Dial Transplant Assoc. 1976;12:259-67.
Both gastrin and acid responses to antral stimulation by meat extracts (Oxo) were studied in 15 undialysed males with chronic renal failure (CRF). Eighteen sex and age-matched duodenal ulcers (DU) served as controls. Oxo increased acid and plasma gastrin in both groups. The rise in plasma gastrin was larger in CRF than in DU. The pattern of gastrin response in CRF suggests accumulation of gastrin in the plasma probably related to impaired renal inactivation of the hormone. Five CRF had large acid responses representing 40 to 90 percent of their maximal secretory capacity. Antral function should be measured in CRF before haemodialysis or renal transplantation.
对15名未透析的慢性肾衰竭（CRF）男性患者和18名年龄及性别匹配的十二指肠溃疡（DU）患者进行了研究，观察了他们对肉提取物（Oxo）刺激胃窦的胃泌素和胃酸反应。Oxo使两组患者的胃酸和血浆胃泌素均升高。CRF组血浆胃泌素的升高幅度大于DU组。CRF患者胃泌素反应模式提示血浆中胃泌素蓄积，这可能与该激素的肾灭活受损有关。5名CRF患者有较大的胃酸反应，占其最大分泌能力的40%至90%。在进行血液透析或肾移植之前，应检测CRF患者的胃窦功能。
