Bergegardh S, Nilsson G, Olbe L
Scand J Gastroenterol. 1976;11(5):475-9.
The effect of antral balloon distension on acid secretion and the plasma gastrin concentration was studied in 8 duodenal ulcer patients. Antral distension significantly increased the acid secretion to about 30% of the peak acid response to pentagastrin without any change in the plasma gastrin concentration. Antral distension and concomitant intragastric neutralization, with the intention of facilitating release of antral gastrin, produced about the same acid response and did not evoke any plasma gastrin increment. The results suggest that the acid response to antral distension in duodenal ulcer patients is evoked without contribution of the gastrin mechanism, and that the acid response is probably mediated via a pyloro-oxyntic reflex. In this respect the duodenal ulcer patient seems to differ from the healthy subject, in whom antral distension produces no acid response, and from the dog, in which release of gastrin as well as pyloro-oxyntic reflex participate in the acid response to antral distension.
在8例十二指肠溃疡患者中研究了胃窦扩张对胃酸分泌和血浆胃泌素浓度的影响。胃窦扩张显著增加胃酸分泌，使其达到对五肽胃泌素最大酸反应的约30%，而血浆胃泌素浓度无任何变化。胃窦扩张并同时进行胃内中和，目的是促进胃窦胃泌素的释放，产生的酸反应大致相同，且未引起血浆胃泌素增加。结果表明，十二指肠溃疡患者对胃窦扩张的酸反应是在胃泌素机制未起作用的情况下诱发的，并且该酸反应可能是通过幽门-泌酸反射介导的。在这方面，十二指肠溃疡患者似乎不同于健康受试者（胃窦扩张在健康受试者中不产生酸反应），也不同于狗（狗对胃窦扩张的酸反应中胃泌素释放以及幽门-泌酸反射均参与其中）。
