Natarajan S, Luthringer D J, Fishbein M C
Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California 90048, USA.
Am J Surg Pathol. 1997 Nov;21(11):1378-80. doi: 10.1097/00000478-199711000-00014.
We report a case of an adenomatoid tumor involving the heart. The lesion was found incidentally at the time of cardiac surgery, measured 1.0 cm, and was poorly demarcated from the adjacent myocardium. Microscopically, the tumor consisted of aggregates of relatively large, epithelioid cells that coalesced to form tubular spaces and occasionally branched into anastomosing channels. The neoplastic cells were strongly immunoreactive with antibodies against cytokeratin. The pathologic features of this unusual cardiac tumor are diagnostic of an adenomatoid tumor, a relatively rare benign neoplasm of mesothelial origin usually found in association with the genital tract. Although rare cases of adenomatoid tumors found outside of the genital tract have been described, including two recently reported pleural tumors, it has not been described to involve the heart.
我们报告一例累及心脏的腺瘤样瘤病例。该病变在心脏手术时偶然发现，大小为1.0厘米，与相邻心肌分界不清。显微镜下，肿瘤由相对较大的上皮样细胞聚集而成，这些细胞融合形成管状间隙，偶尔分支形成吻合通道。肿瘤细胞与细胞角蛋白抗体呈强免疫反应。这种不寻常的心脏肿瘤的病理特征可诊断为腺瘤样瘤，这是一种相对罕见的间皮源性良性肿瘤，通常与生殖道有关。虽然已有文献描述了生殖道外发现的罕见腺瘤样瘤病例，包括最近报道的两例胸膜肿瘤，但尚未见累及心脏的报道。
