脐带血白细胞介素-6水平与新生儿发病率
Umbilical cord blood interleukin-6 levels and neonatal morbidity.
作者信息
Weeks J W, Reynolds L, Taylor D, Lewis J, Wan T, Gall S A
机构信息
Department of Obstetrics and Gynecology, Louisiana State University Medical Center-Shreveport, 71130-3932, USA.
出版信息
Obstet Gynecol. 1997 Nov;90(5):815-8. doi: 10.1016/S0029-7844(97)00421-3.
OBJECTIVE
To study umbilical cord interleukin-6 levels and the occurrence of neonatal sepsis, congenital pneumonia, necrotizing enterocolitis, and grade II-IV intraventricular hemorrhage.
METHODS
Umbilical cord blood was collected from 133 preterm newborns. The study population was divided according to the presence or absence of neonatal complications. Interleukin-6 levels and clinical characteristics were compared by univariate and multivariate analyses.
RESULTS
Sixteen neonates had adverse outcomes, and 117 were unaffected. The median interleukin-6 level was significantly higher in affected than in unaffected infants (145 pg/mL versus 0 pg/mL, P = .002). Elevated interleukin-6 levels were associated independently with neonatal morbidity in multiple logistic regression modeling that included gestational age, birth weight, and antenatal steroid exposure.
CONCLUSION
Umbilical cord blood interleukin-6 levels are elevated in neonates who subsequently develop sepsis, congenital pneumonia, necrotizing enterocolitis, or grade II-IV intraventricular hemorrhage.
目的
研究脐带血白细胞介素-6水平与新生儿败血症、先天性肺炎、坏死性小肠结肠炎及II-IV级脑室内出血的发生情况。
方法
收集133例早产新生儿的脐带血。根据是否存在新生儿并发症对研究人群进行分组。通过单因素和多因素分析比较白细胞介素-6水平和临床特征。
结果
16例新生儿出现不良结局，117例未受影响。受影响婴儿的白细胞介素-6水平中位数显著高于未受影响婴儿（145 pg/mL对0 pg/mL，P = .002）。在包括胎龄、出生体重和产前类固醇暴露的多因素逻辑回归模型中，白细胞介素-6水平升高与新生儿发病独立相关。
结论
随后发生败血症、先天性肺炎、坏死性小肠结肠炎或II-IV级脑室内出血的新生儿脐带血白细胞介素-6水平升高。
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