核小体的曲折：无端的尾巴。

Twists and turns of the nucleosome: tails without ends.

作者信息

Dutnall R N, Ramakrishnan V

机构信息

Department of Biochemistry, University of Utah School of Medicine, Salt Lake City 84132, USA.

出版信息

Structure. 1997 Oct 15;5(10):1255-9. doi: 10.1016/s0969-2126(97)00276-1.

DOI:10.1016/s0969-2126(97)00276-1

PMID:9351811

Abstract

The high-resolution structure of a nucleosome core particle gives us our first detailed look at the primary level of eukaryotic DNA organization. The structure reveals the nature of histone-DNA contacts and provides some surprises regarding the histone tails and their possible involvement in higher levels of chromatin organization.

摘要

核小体核心颗粒的高分辨率结构让我们首次详细了解了真核生物DNA组织的初级水平。该结构揭示了组蛋白与DNA相互作用的本质，并在组蛋白尾巴及其可能参与更高层次染色质组织方面带来了一些意外发现。