Luger K, Richmond T J
ETH-Zürich, Institut für Molekularbiologie und Biophysik, Switzerland.
Curr Opin Struct Biol. 1998 Feb;8(1):33-40. doi: 10.1016/s0959-440x(98)80007-9.
The high resolution structure of the nucleosome core particle of chromatin reveals the form of DNA that is predominant in living cells and offers a wealth of information on DNA binding and bending by the histone octamer. Recent studies imply that chromatin is highly dynamic. This propensity for unfolding and refolding stems from the structural design of the nucleosome core. The histone-fold motif, central to nucleosome structure, is also found in other proteins involved in transcriptional regulation.
染色质核小体核心颗粒的高分辨率结构揭示了活细胞中占主导地位的DNA形式，并提供了关于组蛋白八聚体与DNA结合和弯曲的丰富信息。最近的研究表明染色质具有高度动态性。这种展开和重新折叠的倾向源于核小体核心的结构设计。组蛋白折叠基序是核小体结构的核心，在其他参与转录调控的蛋白质中也有发现。
