Stewart J J, Bass P
Proc Soc Exp Biol Med. 1976 Jun;152(2):213-7. doi: 10.3181/00379727-152-39363.
Intraduodenal infusion of ricinoleic acid and iv bolus injection of the C-terminal octapeptide of cholecystokinin produce markedly similar alterations in the digestive contractile patterns of the GI tract of the unanesthetized dog. The brief, initial stimulation of contractile activity in the proximal small intestine following both procedures is mediated through a cholinergic mechanism. The stimulatory response is followed by an inhibition of digestive contractile activity of unknown origin. These observations suggest that possibility that the GI hormone, cholecystokinin, may mediate the intestinal motor response evoked by infusion of ricinoleic acid directly into the proximal small intestine.
向十二指肠内注入蓖麻油酸以及静脉推注胆囊收缩素的C末端八肽，会使未麻醉犬胃肠道的消化收缩模式发生明显相似的改变。两种操作后近端小肠收缩活动最初的短暂刺激是通过胆碱能机制介导的。刺激反应之后是对来源不明的消化收缩活动的抑制。这些观察结果提示，胃肠激素胆囊收缩素可能介导了将蓖麻油酸直接注入近端小肠所诱发的肠道运动反应。
