Atchison W D, Stewart J J, Bass P
Am J Dig Dis. 1978 Jun;23(6):513-20. doi: 10.1007/BF01072695.
The effects of castor oil and ricinoleic acid on small bowel electrical activity were studied in the fasted conscious dog and were compared to the effects elicited by two nonlaxative oils (triolein and oleic acid). Spike potential activity was monitored at two jejunal sites using unipolar recording electrodes. Castor oil, ricinoleic acid, and triolein produced an increased incidence of basic electrical rhythm (BER) with associated spike potentials when compared to a fasted control; however, the total electrical spiking activity produced by these oils was not statistically different from that induced by feeding. No treatment altered any of the characteristics of BER. A novel pattern of electrical spiking activity was observed in response to the laxatives. This pattern consisted of short repetitive bursts of spike potentials which migrated the length of the recording site. The laxative-induced electrical pattern persisted for several days after treatment with ricinoleic acid or castor oil, and interdigestive patterns were occasionally interrupted for as long as 72 hr. Electrical activity following feeding or the nonlaxative oils consisted of random spike potentials, and normal interdigestive electrical activity resumed within 24 hr. The laxative-induced electrical pattern was shown to be quantitatively distinct from those produced by feeding, fasting, or nonlaxative oils. This pattern may reflect an action of these laxatives on intestinal motility during a diarrheal state.
在禁食的清醒犬中研究了蓖麻油和蓖麻油酸对小肠电活动的影响，并与两种无轻泻作用的油（三油酸甘油酯和油酸）所引发的效应进行了比较。使用单极记录电极在两个空肠部位监测锋电位活动。与禁食对照组相比，蓖麻油、蓖麻油酸和三油酸甘油酯使基本电节律（BER）的发生率增加，并伴有锋电位；然而，这些油所产生的总电峰活动与进食所诱导的活动在统计学上并无差异。没有任何处理改变BER的任何特征。观察到一种对轻泻剂产生反应的新型电峰活动模式。这种模式由短的重复性锋电位爆发组成，这些爆发沿记录部位的长度迁移。在用蓖麻油酸或蓖麻油处理后，轻泻剂诱导的电模式持续数天，消化间期模式偶尔会中断长达72小时。进食或无轻泻作用的油之后的电活动由随机的锋电位组成，正常的消化间期电活动在24小时内恢复。轻泻剂诱导的电模式在数量上与进食、禁食或无轻泻作用的油所产生的模式不同。这种模式可能反映了这些轻泻剂在腹泻状态下对肠道运动的作用。
