Effect of aminooxyacetic acid on audiogenic seizure priming in C57BL/6J and SJL/J mice.

An attempt was made to determine the effects of genetic and temporal factors on the inhibitory action of aminooxyacetic acid on priming for audiogenic seizures. SJL/J and C57BL/6J mice were administered 20 mug/g of AOAA subcutaneously, employing either a 2 hr or 5 hr injection-prime interval, and either a 2 day or a 9 day prime-test interval. It was found that an inhibitory effect on priming occurred only in C57BL/6J mice; this effect was significant only for the 9 day groups, and was observed when wild running was used as the criterion for seizures, but not when clonic convulsion was the criterion. Effects of AOAA are discussed in relation to theories of seizure development through disuse supersensitivity, or by chemical actions on the GABA system.