Gibbs M E
Pharmacol Biochem Behav. 1976 Mar;4(3):305-9. doi: 10.1016/0091-3057(76)90246-x.
When the protein synthesis inhibitor cycloheximide (CXM) is administered just before or soon after a single learning trial, the formation of permanent memory is prevented in day-old chickens. In spite of the blockage of long-term memory, which occurs by 3 hr, Mark and Watts [14] have demonstrated a short-term memory which is independent of protein synthesis and which decays over the 3 hr period. D-amphetamine sulphate, administered subcutaneously (up to 2 hr) after learning to CXM pretreated chickens, held the memory at the level exhibited by the labile memory trace at the time of injection. This close relationship between the amount of labile memory and the time of injection was still apparent 24 hr after learning. These data suggest that, provided there is sufficient labile memory in existence at the time of administration, amphetamine maintains the trace which would otherwise decay and allows it subsequent consolidation into permanent memory at a time later than normal.
当在单次学习试验之前或之后不久给予蛋白质合成抑制剂环己酰亚胺（CXM）时，一日龄雏鸡永久性记忆的形成会受到阻碍。尽管在3小时时会出现长期记忆的阻断，但马克和瓦茨[14]已经证明了一种独立于蛋白质合成且在3小时内衰退的短期记忆。在对经CXM预处理的雏鸡进行学习后皮下注射硫酸右苯丙胺（长达2小时），可将记忆维持在注射时不稳定记忆痕迹所表现出的水平。学习后24小时，不稳定记忆量与注射时间之间的这种密切关系仍然明显。这些数据表明，如果在给药时存在足够的不稳定记忆，苯丙胺会维持原本会衰退的痕迹，并使其在比正常时间更晚的时候随后巩固为永久性记忆。
