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暴露于无毒力克氏锥虫克隆对小鼠随后感染高毒力克隆病程的保护作用。

Protective effect of exposure to non-virulent Trypanosoma cruzi clones on the course of subsequent infections with highly virulent clones in mice.

作者信息

Lauria-Pires L, Teixeira A R

机构信息

Departamento de Patologia, Faculdade de Ciências da Saúde, Universidade de Brasília, Brazil.

出版信息

J Comp Pathol. 1997 Aug;117(2):119-26. doi: 10.1016/s0021-9975(97)80028-x.

Abstract

The protective effect of primary infection with non-virulent Trypanosoma cruzi clones against subsequent infection with highly virulent clones was determined in groups of BALB/c mice. All mice inoculated with the highly virulent m3 and m4 clones succumbed in < or = 16 days. Mice inoculated with the non-virulent h1 and h2 clones survived and were superinfected with the m3 and m4 clones. Low degrees of parasitaemia were observed in mice challenged with the highly virulent clones. The survival ratios of the superinfected mice were not statistically different from those seen in mice that received a single injection of non-virulent T. cruzi. Mice given a non-virulent infection and subsequently challenged with a virulent clone differed from those given only a non-virulent infection in showing more frequently an inflammatory infiltrate in the heart, skeletal muscle and intestines.

摘要

在BALB/c小鼠组中确定了用无毒力的克氏锥虫克隆进行初次感染对随后用高毒力克隆进行感染的保护作用。所有接种高毒力m3和m4克隆的小鼠在≤16天内死亡。接种无毒力h1和h2克隆的小鼠存活下来,并被m3和m4克隆超感染。在用高毒力克隆攻击的小鼠中观察到低程度的寄生虫血症。超感染小鼠的存活率与单次注射无毒力克氏锥虫的小鼠的存活率无统计学差异。接受无毒力感染并随后用毒力克隆攻击的小鼠与仅接受无毒力感染的小鼠不同,前者在心脏、骨骼肌和肠道中更频繁地出现炎症浸润。

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