Paláu M T, Mejía A J, Vergara U, Zúñiga C A
Departamento de Biología, Facultad de Ciencias, Universidad Nacional de Colombia, Bogotá, Colombia.
Mem Inst Oswaldo Cruz. 2003 Jun;98(4):543-8. doi: 10.1590/s0074-02762003000400022. Epub 2003 Aug 18.
In experimental murine infections with Trypanosoma rangeli it has been observed development immune response to Trypanosoma cruzi. The aim of the present work was to analyze the result of antigenic stimuli and the protective effect with T. rangeli in T. cruzi infections. Mice groups immunized with metacyclic trypomastigotes of T. rangeli (Choach -2V strain), derived from haemolymph and salivary gland and reinfected with T. cruzi virulent populations (Tulahuen strain, SA strain and Dm28c clone) from infected in vitro cells, showed decrease severity of disease outcomes, low parasitemia levels and 100% survival of all mice immunized, in comparison with groups infected only with T. cruzi populations, which demonstrated tissue affection, high parasitemia levels and the death of all animals. The above mentioned data contribute to understand the biological behaviour of T. cruzi and T. rangeli and their interaction with vertebrate host.
在对感染克氏锥虫的实验小鼠进行的兰氏锥虫感染实验中，已观察到针对克氏锥虫的免疫反应的发展。本研究的目的是分析抗原刺激的结果以及兰氏锥虫在克氏锥虫感染中的保护作用。用来自血淋巴和唾液腺的兰氏锥虫（Choach -2V株）的循环后期锥鞭毛体免疫小鼠组，并用来自体外感染细胞的克氏锥虫强毒株（图拉亨株、SA株和Dm28c克隆）再次感染，与仅感染克氏锥虫群体的组相比，免疫小鼠组的疾病结局严重程度降低、寄生虫血症水平较低且所有免疫小鼠的存活率为100%，而仅感染克氏锥虫群体的组表现出组织病变、高寄生虫血症水平且所有动物死亡。上述数据有助于了解克氏锥虫和兰氏锥虫的生物学行为及其与脊椎动物宿主的相互作用。
