Boon J P, van der Meer J, Allchin C R, Law R J, Klungsøyr J, Leonards P E, Spliid H, Storr-Hansen E, Mckenzie C, Wells D E
Netherlands Institute for Sea Research (NIOZ), P.O. Box 59, 1790 AB Den Burg, Texel, The Netherlands.
Arch Environ Contam Toxicol. 1997 Oct;33(3):298-311. doi: 10.1007/s002449900257.
Data sets on CB concentrations in fish-eating mammals from five laboratories were combined to test and refine a pharmacokinetic model. Clear differences in PCB patterns were observed between species. The ability to metabolize chlorobiphenyl (CB) congeners with vicinal H-atoms only in the ortho- and meta-positions and with one ortho-chlorine substituent generally increased in the order otter < cetaceans (harbor porpoise, common dolphin) < phocid seals (harbor and grey seal), but the metabolism of congeners with vicinal H-atoms in the meta- and para-positions and with two ortho-chlorines increased in the order cetaceans < seals < otter. Both categories of congeners are probably metabolized by different families of cytochrome P450 (1A and 2B) of which levels apparently differed between the cetaceans, the pinnipeds, and the otter. Within-species CB patterns differed in a concentration-dependent manner. The induction of cytochrome P450 enzymes offers the most likely explanation for this phenomenon, but starvation could have a similar effect on occasion.
来自五个实验室的以鱼类为食的哺乳动物体内多氯联苯（CB）浓度的数据集被合并起来，用于测试和完善一个药代动力学模型。观察到不同物种之间多氯联苯模式存在明显差异。仅在邻位和间位带有相邻氢原子且带有一个邻位氯取代基的氯代联苯（CB）同系物的代谢能力通常按水獭＜鲸类动物（港湾鼠海豚、普通海豚）＜海豹科海豹（港湾海豹和灰海豹）的顺序增加，但在间位和对位带有相邻氢原子且带有两个邻位氯的同系物的代谢能力按鲸类动物＜海豹＜水獭的顺序增加。这两类同系物可能由不同的细胞色素P450家族（1A和2B）代谢，而这些细胞色素P450的水平在鲸类动物、鳍足类动物和水獭之间显然有所不同。物种内的多氯联苯模式随浓度而变化。细胞色素P450酶的诱导作用最有可能解释这一现象，但饥饿偶尔也可能产生类似的效果。
