Sánchez L, Leranoz S, Puig M, Lorén J G, Nikaido H, Viñas M
Laboratori de Microbiologia, Institut Universitari de Salut Pública, Universitat de Barcelona, Spain.
Microbiologia. 1997 Sep;13(3):309-14.
Strains of the facultative anaerobe Haemophilus influenzae, both type b and non typable strains, are frequently multiresistant. The measurement of the antibiotic permeability of Haemophilus influenzae outer membrane (OM) shows that antibiotics can cross through the OM easily. Thus, enzymatic activity or efflux pumps could be responsible for multiresistance. An efflux system closely related to AcrAB of Escherichia coli is present in Haemophilus influenzae. However, their role in multiresistance seems irrelevant. Classical mechanisms such as plasmid exchange seems to be playing a major role in the multidrug resistance in Haemophilus influenzae.
兼性厌氧菌流感嗜血杆菌的菌株，包括b型菌株和不可分型菌株，常常具有多重耐药性。对流感嗜血杆菌外膜（OM）抗生素通透性的测量表明，抗生素能够轻易穿过外膜。因此，酶活性或外排泵可能是多重耐药的原因。流感嗜血杆菌中存在一种与大肠杆菌AcrAB密切相关的外排系统。然而，它们在多重耐药中的作用似乎并不相关。诸如质粒交换等经典机制似乎在流感嗜血杆菌的多药耐药中起主要作用。
