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2

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Differential effects of mutations in tonB1 on intrinsic multidrug resistance and iron acquisition in Pseudomonas aeruginosa.tonB1 基因突变对铜绿假单胞菌固有多药耐药性和铁摄取的不同影响

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2

A genome-scale analysis for identification of genes required for growth or survival of Haemophilus influenzae.一项用于鉴定流感嗜血杆菌生长或存活所需基因的全基因组规模分析。

Proc Natl Acad Sci U S A. 2002 Jan 22;99(2):966-71. doi: 10.1073/pnas.012602299.

3

The role of the TolC family in protein transport and multidrug efflux. From stereochemical certainty to mechanistic hypothesis.TolC家族在蛋白质转运和多药外排中的作用。从立体化学确定性到机制假说。

Eur J Biochem. 2001 Oct;268(19):5011-26. doi: 10.1046/j.0014-2956.2001.02442.x.

4

Antibiotic susceptibility profiles of Escherichia coli strains lacking multidrug efflux pump genes.缺乏多药外排泵基因的大肠杆菌菌株的抗生素敏感性谱

Antimicrob Agents Chemother. 2001 Apr;45(4):1126-36. doi: 10.1128/AAC.45.4.1126-1136.2001.

5

Microbial genome analyses: comparative transport capabilities in eighteen prokaryotes.微生物基因组分析：18种原核生物的比较转运能力

J Mol Biol. 2000 Aug 4;301(1):75-100. doi: 10.1006/jmbi.2000.3961.

6

The acrAB homolog of Haemophilus influenzae codes for a functional multidrug efflux pump.流感嗜血杆菌的acrAB同源物编码一种功能性多药外排泵。

J Bacteriol. 1997 Nov;179(21):6855-7. doi: 10.1128/jb.179.21.6855-6857.1997.

7

Evidence that TolC is required for functioning of the Mar/AcrAB efflux pump of Escherichia coli.有证据表明，TolC是大肠杆菌Mar/AcrAB外排泵发挥功能所必需的。

J Bacteriol. 1996 Oct;178(19):5803-5. doi: 10.1128/jb.178.19.5803-5805.1996.

8

The local repressor AcrR plays a modulating role in the regulation of acrAB genes of Escherichia coli by global stress signals.局部阻遏物AcrR在大肠杆菌acrAB基因受全局应激信号调控的过程中发挥调节作用。

Mol Microbiol. 1996 Jan;19(1):101-12. doi: 10.1046/j.1365-2958.1996.357881.x.

9

Genes acrA and acrB encode a stress-induced efflux system of Escherichia coli.基因acrA和acrB编码大肠杆菌的一种应激诱导外排系统。

Mol Microbiol. 1995 Apr;16(1):45-55. doi: 10.1111/j.1365-2958.1995.tb02390.x.

10

Whole-genome random sequencing and assembly of Haemophilus influenzae Rd.流感嗜血杆菌Rd的全基因组随机测序与组装

Science. 1995 Jul 28;269(5223):496-512. doi: 10.1126/science.7542800.

通过插入失活外排泵突变体的药敏谱鉴定流感嗜血杆菌tolC基因

Identification of the Haemophilus influenzae tolC gene by susceptibility profiles of insertionally inactivated efflux pump mutants.

作者信息

Trepod Catherine M, Mott John E

机构信息

Antibacterials, Pfizer, Groton, Connecticut 06340, USA.

出版信息

Antimicrob Agents Chemother. 2004 Apr;48(4):1416-8. doi: 10.1128/AAC.48.4.1416-1418.2004.

DOI:10.1128/AAC.48.4.1416-1418.2004

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC375248/

Abstract

Isogenic strains containing insertional disruptions of 10 Haemophilus influenzae Rd genes were investigated for their effects on the susceptibility of the organism to various classes of antimicrobial compounds. MIC results show that HI1462, which encodes an Escherichia coli TolC homolog, is the third component of the H. influenzae AcrAB pump.

摘要

对含有10个流感嗜血杆菌Rd基因插入性破坏的同基因菌株进行了研究，以考察其对该生物体对各类抗菌化合物敏感性的影响。最低抑菌浓度（MIC）结果显示，编码大肠杆菌TolC同源物的HI1462是流感嗜血杆菌AcrAB泵的第三个组分。