爱泼斯坦-巴尔病毒与霍奇金淋巴瘤相关性研究。

Study of association of Epstein Barr-virus with Hodgkin's disease.

作者信息

Radha K, Shanthi P, Madhavan M, Senthamarai A

机构信息

Department of Pathology, Dr. A.L. Mudaliar Postgraduate Institute of Basic Medical Science, University of Madras, Taramani.

出版信息

Indian J Pathol Microbiol. 1997 Jul;40(3):351-4.

PMID:9354006

Abstract

Epstein Barr-Virus (EBV) is a lymphotropic herpes virus, well recognised for its oncogenic properties. In recent years substantial evidence has accumulated supporting a role for EBV in the pathogenesis of Hodgkin's disease. The epidemiologic and histologic features of Hodgkin's disease (HD) have long indicated a possible infective cause. Our study involves the detection of the EBV encoded latent membrane protein 1 (LMP-1) in 45 cases of Hodgkin's disease using immunohistochemical methods. In this study we detected LMP-1 positivity in the Reed-Sternberg and Hodgkin's cells in 31% of cases of HD. In mixed cellularity the positivity was 21.7% while nodular sclerosis exhibited positivity of 50% of the cases. The lymphocyte depletion subtype showed 100% positivity. All cases of lymphocyte predominance and the single unclassified case were negative for LMP. The demonstration of LMP-1 in Hodgkin's disease has important implications since it is one of the latent gene products which produces B Lymphocyte transformation.

摘要

爱泼斯坦-巴尔病毒（EBV）是一种嗜淋巴细胞性疱疹病毒，因其致癌特性而广为人知。近年来，大量证据不断积累，支持EBV在霍奇金淋巴瘤发病机制中发挥作用。长期以来，霍奇金淋巴瘤（HD）的流行病学和组织学特征表明可能存在感染性病因。我们的研究采用免疫组化方法检测了45例霍奇金淋巴瘤中EBV编码的潜伏膜蛋白1（LMP-1）。在本研究中，我们在31%的HD病例的里德-斯腾伯格细胞和霍奇金细胞中检测到LMP-1阳性。在混合细胞型中，阳性率为21.7%，而结节硬化型的阳性率为50%。淋巴细胞消减型显示阳性率为100%。所有淋巴细胞为主型病例及单个未分类病例的LMP均为阴性。霍奇金淋巴瘤中LMP-1的证实具有重要意义，因为它是产生B淋巴细胞转化的潜伏基因产物之一。