Karlic H, Möstl M, Mucke H, Pavlova B, Pfeilstöcker M, Heinz R
L. Boltzmann Institute for Leukemia Research and Hematology, Hanusch Hospital, Vienna, Austria.
Cancer Res. 1997 Nov 1;57(21):4718-21.
In addition to a few disorders such as acute T-cell leukemia that are typically associated with the human T-cell leukemia virus (HTLV) 1 in endemic regions, this virus may also play a role in some other hematological diseases. Here, we examine the incidence of HTLV in hematological diseases from a nonendemic region in central Europe. Data obtained by PCR and/or serological techniques from a total of 730 cases showed that besides the expected presence of HTLV-1 in T-lymphoid diseases (2 of 27 cases), HTLV-1 was only detected in myelodysplastic syndrome (MDS), in which an incidence of 17% (11 of 65 cases) was found. A correlation with a history of multiple transfusions or treatment with blood products in the HTLV-1-positive MDS could not be ascertained. Cytogenetics detected the presence of del(5)(q) in six HTLV-positive cases (five MDS and one T-cell acute lymphocytic leukemia) but in only one HTLV-negative case. These data indicate that allelic deletions of a series of 5q-located genes that typically occur in MDS may be associated with HTLV infections in central Europe.
除了在流行地区通常与人类T细胞白血病病毒（HTLV）1相关的少数疾病，如急性T细胞白血病外，这种病毒也可能在其他一些血液疾病中起作用。在这里，我们研究了来自中欧非流行地区血液疾病中HTLV的发病率。通过PCR和/或血清学技术从总共730例病例中获得的数据表明，除了在T淋巴细胞疾病中预期存在HTLV-1（27例中有2例）外，仅在骨髓增生异常综合征（MDS）中检测到HTLV-1，其发病率为17%（65例中有11例）。在HTLV-1阳性的MDS中，无法确定与多次输血史或血液制品治疗之间的相关性。细胞遗传学在6例HTLV阳性病例（5例MDS和1例T细胞急性淋巴细胞白血病）中检测到del(5)(q)的存在，但仅在1例HTLV阴性病例中检测到。这些数据表明，在中欧，通常发生在MDS中的一系列位于5q的基因的等位基因缺失可能与HTLV感染有关。
