Noguchi M, Eguchi Y, Ichiki J, Yahara J, Noda S
Department of Urology, Kurume University School of Medicine, Japan.
Int J Urol. 1997 Sep;4(5):480-3. doi: 10.1111/j.1442-2042.1997.tb00289.x.
Urinary incontinence is one of the most common complications occurring after radical prostatectomy. We evaluated the efficacy of clenbuterol, a selective beta 2-adrenoceptor agonist, in the treatment of incontinence occurring after radical prostatectomy, using urodynamic assessment.
Fourteen men (mean age, 68 years) with post-radical-prostatectomy incontinence were treated with 20 mg of clenbuterol twice a day for 1 month. The urodynamic assessment was performed on all patients before and after the administration of clenbuterol. A pad scoring system was used to gauge the severity of incontinence before and after treatment.
At 1 month after administration of clenbuterol, 9 of the 14 patients (64%) had dramatic improvement in pad scores. Treatment failed in 5 patients (36%) with severe incontinence. The results of urodynamic studies showed that the mean functional urethral length of the patients with post-radical-prostatectomy incontinence increased significantly after treatment.
These results suggest that clenbuterol can be used as an effective agent for treating mild-to-moderate stress incontinence after radical prostatectomy.
尿失禁是根治性前列腺切除术后最常见的并发症之一。我们使用尿动力学评估，评估了选择性β2肾上腺素能受体激动剂克伦特罗对根治性前列腺切除术后发生的尿失禁的治疗效果。
14名根治性前列腺切除术后出现尿失禁的男性（平均年龄68岁），每天两次服用20毫克克伦特罗，持续1个月。在服用克伦特罗前后，对所有患者进行尿动力学评估。使用护垫评分系统来衡量治疗前后尿失禁的严重程度。
服用克伦特罗1个月后，14名患者中有9名（64%）护垫评分有显著改善。5名（36%）重度尿失禁患者治疗失败。尿动力学研究结果显示，根治性前列腺切除术后尿失禁患者的平均功能性尿道长度在治疗后显著增加。
这些结果表明，克伦特罗可作为治疗根治性前列腺切除术后轻至中度压力性尿失禁的有效药物。
