Cattenoz Pierre B, Monticelli Sara, Pavlidaki Alexia, Giangrande Angela
Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France.
Centre National de la Recherche Scientifique, UMR 7104, Illkirch, France.
Front Cell Dev Biol. 2021 Mar 4;9:643712. doi: 10.3389/fcell.2021.643712. eCollection 2021.
The catalog of the immune cells was until recently limited to three major cell types, based on morphology, function and few molecular markers. Three recent single cell studies highlight the presence of several subgroups, revealing a large diversity in the molecular signature of the larval immune cells. Since these studies rely on somewhat different experimental and analytical approaches, we here compare the datasets and identify eight common, robust subgroups associated to distinct functions such as proliferation, immune response, phagocytosis or secretion. Similar comparative analyses with datasets from different stages and tissues disclose the presence of larval immune cells resembling embryonic hemocyte progenitors and the expression of specific properties in larval immune cells associated with peripheral tissues.
直到最近，基于形态学、功能和少数分子标记，免疫细胞的分类还仅限于三种主要细胞类型。最近的三项单细胞研究突出了几个亚群的存在，揭示了幼虫免疫细胞分子特征的巨大多样性。由于这些研究依赖于略有不同的实验和分析方法，我们在此比较数据集，并识别出与增殖、免疫反应、吞噬作用或分泌等不同功能相关的八个常见、稳定的亚群。对来自不同阶段和组织的数据集进行的类似比较分析揭示，存在类似于胚胎血细胞祖细胞的幼虫免疫细胞，以及与外周组织相关的幼虫免疫细胞中特定特性的表达。
