Pedemonte W A, Mosnaim A D, Bulat M
Res Commun Chem Pathol Pharmacol. 1976 May;14(1):111-6.
Labeled phenylacetic acid (14C-PAA) penetrates blood-cerebrospinal fluid (CSF) barrier in cats only under a high gradient of concentration; under these conditions the administration of large doses of either PAA or probenecid decreases the plasma:CSF 14C-PAA ratio. 14C-PAA is quickly removed from the CSF and blood and is excreted into urine; this excretion is blocked by probenecid. It appears, therefore, that PAA crosses the blood-CSF barrier with difficulty and that is secreted by the kidney.
标记的苯乙酸（14C-PAA）仅在高浓度梯度下才能穿透猫的血脑脊髓液（CSF）屏障；在这些条件下，给予大剂量的PAA或丙磺舒会降低血浆：CSF 14C-PAA比值。14C-PAA能迅速从脑脊液和血液中清除，并排泄到尿液中；丙磺舒可阻断这种排泄。因此，似乎PAA难以穿过血脑屏障，且由肾脏分泌。
