Sandler M, Ruthven C R, Goodwin B L, Lees A, Stern G M
J Neurol Neurosurg Psychiatry. 1982 Apr;45(4):366-8. doi: 10.1136/jnnp.45.4.366.
In a group of six Parkinsonian patients and 13 "controls" with non-Parkinsonian neurological disease, there was a high correlation between both free and conjugated phenylacetic acid concentrations in plasma and cerebrospinal fluid taken at about the same time. This compound is the major metabolite of phenylethylamine, the production of which may be disturbed in a number of neuropsychiatric illnesses. Thus plasma measurements might be employed clinically to provide an estimate of central changes in phenylethylamine economy. A small but significantly higher proportion of conjugated phenylacetic acid was present in the plasma (but not cerebrospinal fluid) of Parkinsonians compared with controls.
在一组6名帕金森病患者和13名患有非帕金森病神经系统疾病的“对照者”中，大约在同一时间采集的血浆和脑脊液中游离和结合型苯乙酸浓度之间存在高度相关性。这种化合物是苯乙胺的主要代谢产物，其生成在一些神经精神疾病中可能受到干扰。因此，血浆检测可在临床上用于评估苯乙胺代谢的中枢变化。与对照者相比，帕金森病患者血浆中（而非脑脊液中）结合型苯乙酸的比例虽小但显著更高。
