West R, Hajek P
St. George's Hospital Medical School, University of London, England.
Am J Psychiatry. 1997 Nov;154(11):1589-92. doi: 10.1176/ajp.154.11.1589.
DSM-IV lists increased anxiety as a nicotine withdrawal symptom. Increased anxiety has been reported to follow smoking cessation in most but not all studies. Indeed, there is some evidence for a reduction in anxiety, compared with precessation levels, after the first few weeks of abstinence. This study reports data from 101 smokers who attempted to stop smoking and who satisfied DSM-III-R criteria for nicotine dependence.
Unlike most studies in this area, a strict criterion of lapse-free abstinence was adopted. It is argued that lapses during an attempt at cessation may underlie a transient increase in anxiety. Anxiety was measured both by a single rating typical in withdrawal studies and by the State-Trait Anxiety Inventory--State Form X. Patients were rated 2 weeks and 1 week before cessation, immediately before cessation, 24 hours after cessation, and 1, 2, 3, and 4 weeks after cessation.
Seventy patients were abstinent for the 4-week follow-up period. There was no evidence of an increase in anxiety following smoking cessation. However, there was a significant decrease in anxiety from the first week of abstinence.
The results weaken the view that increased anxiety is a robust and central element of the nicotine withdrawal syndrome and suggest that giving up smoking is quite rapidly followed by a reduction in anxiety that may reflect removal of an anxiogenic agent, nicotine.
《精神疾病诊断与统计手册》第四版(DSM-IV)将焦虑加剧列为尼古丁戒断症状。多数但并非所有研究均报告称,戒烟后会出现焦虑加剧的情况。事实上,有证据表明,在戒烟后的头几周,与戒烟前相比,焦虑有所减轻。本研究报告了101名试图戒烟且符合DSM-III-R尼古丁依赖标准的吸烟者的数据。
与该领域的多数研究不同,本研究采用了严格的无复吸戒烟标准。有人认为,戒烟尝试期间的复吸可能是焦虑短暂加剧的原因。通过戒断研究中常用的单一评分以及状态-特质焦虑量表-状态形式X来测量焦虑程度。在戒烟前2周和1周、戒烟即刻、戒烟后24小时以及戒烟后1、2、3和4周对患者进行评分。
70名患者在4周的随访期内成功戒烟。没有证据表明戒烟后焦虑会加剧。然而,从戒烟第一周起,焦虑显著降低。
这些结果削弱了焦虑加剧是尼古丁戒断综合征的一个稳固且核心要素的观点,并表明戒烟后焦虑会迅速减轻,这可能反映出一种致焦虑剂尼古丁被消除了。