Dardzinski B J, Mosher T J, Li S, Van Slyke M A, Smith M B
Department of Radiology, Pennsylvania State University College of Medicine, Milton S. Hershey Medical Center, Hershey 17033, USA.
Radiology. 1997 Nov;205(2):546-50. doi: 10.1148/radiology.205.2.9356643.
To determine the spatial variation of in vivo cartilage T2 in young asymptomatic adults.
Quantitative T2 maps of seven asymptomatic young male adults and one male volunteer with a history of previous intraarticular chondroid fragments were calculated by using a multiecho, spin-echo magnetic resonance imaging sequence at 3.0 T. The T2 maps were bilinearly interpolated to generate T2 profiles across the thickness of cartilage.
All seven asymptomatic volunteers demonstrated a monotonic increase in T2, which increased from 32 msec +/- 1 in the deep radial zone and 48 msec +/- 1 in the deep transitional zone to 67 msec +/- 2 in the outer transitional superficial zone. The T2 profile of the volunteer with superficial fibrillation observed at arthroscopy demonstrated marked spatial heterogeneity and a statistically significant increase in cartilage T2.
There is a reproducible pattern of increasing T2 that is proportional to the known spatial variation in cartilage water and is inversely proportional to the distribution of proteoglycans. The authors postulate that these regional T2 differences are secondary to the restricted mobility of cartilage water within an anisotropic solid matrix.
确定年轻无症状成年人体内软骨T2的空间变化。
使用3.0 T的多回波自旋回波磁共振成像序列，计算7名无症状年轻男性成年人和1名有既往关节内软骨样碎片病史的男性志愿者的定量T2图。对T2图进行双线性插值，以生成跨软骨厚度的T2剖面图。
所有7名无症状志愿者的T2均呈单调增加，从深放射状带的32毫秒±1增加到深过渡带的48毫秒±1，再到外过渡浅表带的67毫秒±2。关节镜检查时观察到有浅表纤维化的志愿者的T2剖面图显示出明显的空间异质性，且软骨T2有统计学意义的增加。
存在T2增加的可重复模式，该模式与软骨水的已知空间变化成正比，与蛋白聚糖的分布成反比。作者推测，这些区域T2差异继发于各向异性固体基质内软骨水的流动性受限。
